Frederick Weber
Frederick Parkes Weber (1863-1972) was an English physician
Overview
Eponym
Biography
- Born May 8, 1863, elder son of Sir Hermann Weber (1823-1918)
- Died June 2, 1962
Medical Eponyms
Klippel-Trénaunay-Weber syndrome (1900)
Klippel-Trenaunay syndrome (KTS) is a rare congenital cutaneous vascular malformation syndrome. Diagnosis is made with two of the three classic signs of localised cutaneous capillary malformations, venous abnormalities, and limb hypertrophy.
Also known as capillary-lymphatic-venous malformation (CLVM). It is associated with a a wide spectrum of clinical findings that can manifest during infancy and can progress throughout childhood and adulthood.
This syndrome is part of the PIK3CA-related overgrowth spectrum of diseases, which are caused by mutations in the PIK3CA gene.
1900 – Maurice Klippel (1858-1942) and Paul Trénaunay (1875-1938) reported a patient with asymmetrical hypertrophy of the soft tissue and bone, together with haemangiomatous lesions of the skin, using the term “naevus variqueux ostéo-hypertrophique”
1907 – Weber described three more cases and proposed the classic triad of “dermal naevi, osseous and soft tissue hemihypertrophy, and varicose veins.“
1918 – Weber added the additional component of arteriovenous fistulae and thereafter the triple eponym came into use.
Peutz-Jeghers syndrome
1896 – Sir Jonathan Hutchinson published the portraits and further description of the twins described by Connor in his article titled ‘Pigmentation of lip and mouth‘. He wrote that these twins “developed a number of black pigmented spots on the lips and inside of the mouth“, which had increased in size and number since appearing at three-years of age
1919 – Weber published an update on the twins, confirming that one of the twins died following a surgical procedure for intussusception at age 20-years. Intestinal polyposis was not specifically confirmed as the cause of intussusception. The second twin died at age 52-years of breast cancer, confirmed by her brother to Harold Joseph Jeghers (1904-1990)
Pfeifer-Weber-Christian disease
Rendu-Osler-Weber disease
Sturge-Weber syndrome
Weber-Cockayne syndrome
Major Publications
- Weber FP. Angioma-formation in connection with hypertrophy of limbs and hemi-hypertrophy.
British Journal of Dermatology. 1907; 19: 231-235. [Klippel-Trénaunay-Weber syndrome] - Weber FP. Hemangiectatic hypertrophy of Limbs – congenital phlebarteriectasis and so-called congenital varicose veins. British Journal of Children’s Diseases, 1918; 25: 13. [Klippel-Trénaunay-Weber syndrome]
- Weber FP. Aspects of death and correlated aspects of life in art, epigram, and poetry : contributions towards an anthology and an iconography of the subject. 1918
- Weber FP. Patches of deep pigmentation of the oral mucous membrane not connected with Addison’s disease. Quarterly Journal of Medicine. 1919; 12: 404-408. [Peutz-Jeghers syndrome]
References
Biography
Eponymous terms
- Klippel M, Trénaunay P. Du naevus variqueux ostéo-hypertrophique. Archives générales de médecine, 1900; 3: 641-672.
Eponym
the person behind the name
